NCT07462754

Effect of Fire-Needle Combined With Regular Acupuncture on Pregnancy Outcome in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Huazhong University of Science and Technology · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture. A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture). Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.

Conditions

• Implantation Failure

Interventions

Type	Name	Description
OTHER	no acupuncture	no acupuncture
DEVICE	regular acupuncture	Regular acupuncture
DEVICE	Fire needle combination group	fire needle combination group (receiving both fire needle and regular acupuncture)

Timeline

• Start date: 2024-07-01
• Primary completion: 2025-06-30
• Completion: 2025-10-31
• First posted: 2026-03-10
• Last updated: 2026-03-10

Locations

1 site across 1 country: China