NCT07462702

Topical Minocycline for CARP

Topical Minocycline Foam for Treatment of Confluent and Reticulated Papillomatosis (CARP)

• Status: Not Yet Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 35 (estimated)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 9 Years
• Healthy volunteers: Not accepted

Summary

This proof-of-concept trial evaluates the efficacy, safety, and patient satisfaction of topical minocycline foam (AMZEEQ®) in patients aged 9 and older with confluent and reticulated papillomatosis (CARP). Participants will apply AMZEEQ® to one side of the body and a topical emollient to the other for 5 weeks, followed by an optional extension period. The study aims to assess whether topical minocycline is a well-tolerated and effective alternative to oral antibiotics.

Detailed description

Confluent and reticulated papillomatosis (CARP) is a dermatologic condition consisting of primarily truncal hyperpigmented and hyperkeratotic papules and macules in adolescents. The exact cause is unclear, though a gram-positive actinomycete, Dietzia papillomatosis, likely plays a role. Resolution of the rash could take a year or even years to fully occur. While the gold-standard is to treat with oral minocycline (100 mg daily), preliminary data suggests that topical minocycline may be effective as well. A case report of a 51-year-old female documents clearance with topical minocycline foam. Other antibiotics can be considered as well, such as azithromycin and erythromycin. Antifungal medications can also be considered as well as topicals such as tretinoin, tacrolimus, and urea. Oral minocycline has a number of side effects and cannot be used in pregnancy. Given side effects and risks of lengthy oral antibiotic treatment, investigators believe that utilization of topical minocycline foam could be a suitable option for patients, especially those who do not want to be treated with oral minocycline for an extended period of time.

Conditions

• Confluent and Reticulated Papillomatosis (CARP)

Interventions

Type	Name	Description
DRUG	Topical Minocycline Foam FXFM244	Topical minocycline foam that will be applied to half of the subject's body that will be chosen by the subject.
OTHER	Control	Control topical emollient that will be applied to the contralateral half of the body.

Timeline

• Start date: 2026-06-01
• Primary completion: 2027-06-01
• Completion: 2027-12-01
• First posted: 2026-03-10
• Last updated: 2026-03-10

Regulatory

• FDA-regulated drug study