NCT07462273

RISS Block for Enhanced Recovery After Video-Assisted Thoracoscopic Surgery

A Prospective Randomized Controlled Trial Evaluating the Efficacy and Safety of Ultrasound-Guided Rhomboid Intercostal and Subserratus Plane Block for Enhanced Recovery After Video-Assisted Thoracoscopic Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Ningbo University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This prospective randomized controlled trial evaluates the efficacy and safety of ultrasound-guided rhomboid intercostal and subserratus plane (RISS) block for postoperative analgesia in patients undergoing video-assisted thoracoscopic surgery (VATS). Postoperative pain after VATS can impair respiratory function, delay mobilization, and increase opioid consumption. Although several regional anesthesia techniques are available, the optimal analgesic strategy remains under investigation. The RISS block is a novel fascial plane block that may provide effective thoracic analgesia while minimizing opioid-related adverse effects. A total of 90 adult patients scheduled for elective VATS will be randomly assigned to receive either ultrasound-guided RISS block combined with general anesthesia or general anesthesia alone. The primary outcomes include postoperative 24-hour benefit of analgesia score (BCS) and patient-controlled intravenous analgesia (PCIA) pressing frequency. Secondary outcomes include postoperative pain scores, opioid consumption, and adverse events. This study aims to determine whether RISS block improves postoperative recovery and reduces opioid requirements after VATS.

Conditions

• Postoperative Pain
• Thoracic Surgery
• Video-Assisted Thoracic Surgery

Interventions

Type	Name	Description
PROCEDURE	Rhomboid Intercostal and Subserratus Plane Block with local anesthetic	Ultrasound-guided dual-plane RISS block performed after induction of general anesthesia. A total of 40 mL of 0.375% ropivacaine (150 mg) was administered across the rhomboid-intercostal plane and low subserratus plane.
PROCEDURE	Intercostal nerve block	Ultrasound-guided intercostal nerve block performed at surgical port levels (T4-T7) using 0.375% ropivacaine with total dose ≤75 mg.

Timeline

• Start date: 2024-09-01
• Primary completion: 2025-09-01
• Completion: 2025-10-01
• First posted: 2026-03-10
• Last updated: 2026-03-10

Locations

1 site across 1 country: China