NCT07461103

Effect of Topical Insulin on Healing Rate of Pemphigus Lesions

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the efficacy of topical insulin in promoting healing of pemphigus vulgaris erosions. Twenty patients with pemphigus vulgaris were enrolled, each contributing three comparable lesions randomly allocated to receive long-acting insulin (insulin glargine), short-acting insulin (regular insulin), or normal saline control. Treatments were applied topically twice daily for 14 days or until complete healing.

Conditions

• Pemphigus Vulgaris
• Skin Erosion
• Autoimmune Blistering Disease

Interventions

Type	Name	Description
DRUG	insulin glargine	Topical application of insulin glargine (100 IU/mL) at dose of 0.1 mL per 10 cm² lesion area, applied twice daily using insulin syringe spray technique for 14 days or until complete healing
DRUG	human insulin	topical application of regular insulin (100 IU/mL) at dose of 0.1 mL per 10 cm² lesion area, applied twice daily using insulin syringe spray technique for 14 days or until complete healing
DRUG	0.9% Normal Saline	Topical application of 0.9% normal saline at dose of 0.1 mL per 10 cm² lesion area, applied twice daily using insulin syringe spray technique for 14 days or until complete healing

Timeline

• Start date: 2024-06-22
• Primary completion: 2025-08-10
• Completion: 2025-08-10
• First posted: 2026-03-10
• Last updated: 2026-03-10

Locations

1 site across 1 country: Egypt