NCT07460869

Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar

Concentrated Growth Factor Versus Platelets-rich Fibrin in Revascularization of Immature Necrotic Mandibular First Permanent Molar.

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Minia University · Academic / Other
• Sex: All
• Age: 6 Years – 8 Years
• Healthy volunteers: Accepted

Summary

in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients

Detailed description

children 6-8 yrs were selected for this study because the roots of mandibular first permanent molar is not completed. then access cavity is opened, irrigation protocol is applied, intracanal medication is applied and the cavity is sealed with temporary filling. after three weeks blood sample is obtained from patients to get CGF and PRF membranes. temporary filling is removed . intracanal medication is removed, over instrumentation is done to get some intracanal blood the wait tell blood clot is formed then CGF or PRF is applied on the clot the bio dentine is applied and cavity is sealed with composite restoration

Conditions

• Revascularization of Immature Young Permenant Teeth

Interventions

Type	Name	Description
BIOLOGICAL	Revascularization/Conservative management	Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine

Timeline

• Start date: 2025-01-10
• Primary completion: 2026-07-10
• Completion: 2027-07-10
• First posted: 2026-03-10
• Last updated: 2026-03-10

Locations

1 site across 1 country: Egypt