NCT07460622

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

E-cigarette Prevention and Emotion Regulation: Virtual Reality Intervention for Adolescents

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,251 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 11 Years – 15 Years
• Healthy volunteers: Accepted

Summary

This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school students in real-world classrooms. If successful, E-invite Only VR has the potential to prevent adolescents from experiencing a multitude of poor health outcomes related to nicotine vaping, including cancer.

Detailed description

After the 12-month follow-up period, schools in the control arm will receive access to the E-Invite Only VR intervention, allowing students and staff to utilize the program as part of their regular health education curriculum. The clinical trial portion of this study will be informed by preliminary focus groups and surveys.

Conditions

• E-cigarette Use/Vaping Prevention
• Nicotine Dependence Prevention
• Adolescent Mental Health

Interventions

Type	Name	Description
BEHAVIORAL	Virtual Reality E-Cigarette Prevention Program	The E-Invite Only VR intervention is a school-based, virtual reality (VR) e-cigarette prevention program designed for 8th-grade students. It is an enhanced version of the Invite Only VR game, incorporating mental health promotion content alongside e-cigarette prevention education. The intervention leverages interactive gameplay to build emotion regulation skills and increase students' ability to resist peer pressure to use e-cigarettes. It aligns with behavior change theories, including the Theory of Planned Behavior and Social Cognitive Theory, to improve knowledge, harm perceptions, and self-efficacy related to vaping prevention

Timeline

• Start date: 2026-10-01
• Primary completion: 2028-06-01
• Completion: 2028-06-01
• First posted: 2026-03-10
• Last updated: 2026-03-10

Locations

1 site across 1 country: United States