NCT07458165

From a Single Child to Family Planning

From Single Child to Family Planning: Determinants of Returning to ART to Build the Desired Family in a Monocentric Italian Cohort.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,852 (actual)
• Sponsor: Istituto Clinico Humanitas · Academic / Other
• Sex: All
• Age: 18 Years – 43 Years
• Healthy volunteers: Not accepted

Summary

This monocentric retrospective cohort study aims to investigate reproductive behavior and subsequent family-building outcomes in couples who achieved a first live birth through assisted reproductive technology (ART) at a university-affiliated fertility center in Italy. All couples obtaining a first live birth between January 2010 and December 2020 will be included and followed until December 2024. The primary objective is to evaluate the rate of return for further ART treatment after the first live birth. Secondary objectives include assessing cumulative live birth rate (CLBR) for the second and third live birth. Associations between return behavior and clinical factors, including maternal age, presence of cryopreserved oocytes or embryos, and treatment characteristics, will be analyzed.

Conditions

• Infertility Assisted Reproductive Technology

Timeline

• Start date: 2010-01-01
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2026-03-09
• Last updated: 2026-03-10