NCT07456904

Outcomes of Health Care Transition for AYA With a Cancer Predisposition

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 56 (estimated)
• Sponsor: St. Jude Children's Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This observational study evaluates whether adolescents and young adults (AYAs) with a cancer predisposition syndrome (CPS) establish and maintain adult health care and continue CPS-specific cancer surveillance after graduating from pediatric care at St. Jude Children's Research Hospital (SJCRH). Participants will complete a Readiness Assessment and periodic surveys over 8 years post-graduation. Primary Objectives * To evaluate whether adolescents and young adults (AYAs) with a cancer predisposition syndrome (CPS) report they have established care with adult health care providers and pursue CPS-specific cancer surveillance within 1-year post-graduation from SJCRH. * To evaluate whether AYAs with CPS report they maintain care with adult health care providers and continue CPS-specific cancer surveillance 3 years post-graduation from SJCRH. Exploratory Objectives: * To evaluate whether AYAs with CPS report they continue to maintain care with adult health care providers and complete CPS-specific cancer surveillance longitudinally 5 years and 8 years post-graduation from St. Jude Children's Research Hospital (SJCRH). * To examine clinical correlates of establishing care with adult providers and initiating CPS-specific cancer surveillance post-graduation from SJCRH. * To identify the tumors diagnosed in AYAs with CPS after they graduate from SJCRH and determine how these tumors were identified (i.e., through specific surveillance tests or based on symptoms). * To identify barriers and facilitators AYAs face when establishing and maintaining adult health care and pursuing CPS-specific cancer surveillance.

Detailed description

The OnTRAC study investigates the outcomes of AYAs with CPS following their transition from pediatric to adult health care. The study aims to assess whether participants establish care with adult providers and adhere to recommended cancer surveillance protocols. Participants will complete a Readiness Assessment one month post-graduation and electronic Transition Outcomes Surveys at 1, 3, 5, and 8 years. These surveys will evaluate health care engagement, cancer screening adherence, barriers and facilitators to care, and psychosocial experiences. The study will also explore clinical and demographic correlates of successful transition and surveillance adherence.

Conditions

• Genetic Predisposition

Interventions

Type	Name	Description
BEHAVIORAL	Readiness Assessment	Electronic assessment administered 1 month post-graduation to evaluate transition preparedness.
BEHAVIORAL	Transition Outcomes Survey A	Administered at 1 and 3 years post-graduation to assess health care engagement and psychosocial outcomes.
BEHAVIORAL	Transition Outcomes Survey B	Administered at 5 and 8 years post-graduation to assess long-term outcomes and cancer surveillance adherence.

Timeline

• Start date: 2026-06-01
• Primary completion: 2034-11-01
• Completion: 2037-11-01
• First posted: 2026-03-09
• Last updated: 2026-04-01

Locations

1 site across 1 country: United States