NCT07456267

Plant miRNAs In Human Plasma After Broccoli Consumption

Detection Of Plant miRNAs After Broccoli Consumption In Human Plasma: Role Of "Cross-Kingdom" Regulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: IMDEA Food · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Nutritional clinical study to evaluate the absorption and presence of exogenous miRNAs from broccoli in plasma and peripheral blood mononuclear cells (PBMCs) and to determine their possible implication in the modulation of fecal miRNAs and gut microbiota in healthy volunteers.

Detailed description

Nutritional clinical study to evaluate the absorption and presence of exogenous miRNAs from broccoli in plasma and in peripheral blood mononuclear cells (PBMCs) and determine their possible involvement in the modulation of fecal miRNAs and gut microbiota in healthy volunteers. For this purpose, two nutritional interventions will be carried out: the first will consist of an acute intake to evaluate the pharmacokinetics of exogenous miRNAs of broccoli in human plasma, and the second will be a sustained daily intake of 200g broccoli for a duration of 2 weeks.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Broccoli consumption	Clinical-nutritional intervention involving two studies: 1) study to evaluate the pharmacokinetics of exogenous miRNAs in human plasma after acute intake of 200g of broccoli, and 2) sustained study where volunteers intake 200g of broccoli daily, for 2 weeks.

Timeline

• Start date: 2025-02-14
• Primary completion: 2025-03-14
• Completion: 2025-03-14
• First posted: 2026-03-06
• Last updated: 2026-03-06

Locations

1 site across 1 country: Spain