NCT07456254

Effect of 0° and 50° N-K Table Load Angles on Quadriceps Activation in Knee Osteoarthritis

Comparative Effectiveness of N-K Table Load Angles at 0° and 50° on Quadriceps Femoris Maximum Voluntary Contraction in Patients With Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: Female
• Age: 50 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Knee osteoarthritis (OA) is a common degenerative joint disease that leads to pain, reduced mobility, and functional limitation. Quadriceps femoris weakness plays a significant role in disease progression and disability. Isotonic strengthening using the N-K Table allows adjustment of load angles to optimize muscle activation; however, the effect of different load angles on quadriceps activation in patients with knee osteoarthritis remains unclear. This study aims to compare quadriceps femoris activation at 0° and 50° N-K Table load angles in patients with knee osteoarthritis using surface electromyography (sEMG). A randomized cross-over experimental design is applied to determine whether adjusting the load angle improves maximum voluntary contraction (MVC) during isotonic knee extension exercise.

Detailed description

Knee osteoarthritis (OA) is the most prevalent joint disease and a leading cause of disability among older adults. The progressive degeneration of articular cartilage and structural remodeling of the joint result in chronic pain, stiffness, and limited movement. Among the factors contributing to disability, quadriceps femoris weakness plays a central role by impairing knee stability and shock absorption during gait. Isotonic strengthening exercises using the N-K Table provide a controlled method to restore quadriceps strength while minimizing excessive joint loading. The N-K Table allows adjustment of the load arm angle, which may better align external resistance with the physiological torque profile of the knee extensors, including the vastus medialis, vastus lateralis, and rectus femoris. Although previous studies in healthy adults suggest that higher load angles may optimize torque production, the specific effect in patients with knee osteoarthritis has not been clearly established. This study employed a randomized cross-over experimental design. A total of 43 female participants aged 50-65 years with unilateral or bilateral knee osteoarthritis (Kellgren-Lawrence grade 2-3) were enrolled. Each participant performed isotonic knee extension exercises at 0° and 50° N-K Table load angles in random order. Exercise intensity was set at 75% of the individual ten-repetition maximum (10RM). Surface electromyography (sEMG) was used to measure maximum voluntary contraction (MVC) of the vastus medialis, vastus lateralis, and rectus femoris. The primary outcome was the difference in MVC between the two load angles. Secondary variables included age, body mass index, and physical activity level. The study was conducted at the Department of Physical Medicine and Rehabilitation, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, between January and June 2024. Ethical approval was obtained from the institutional ethics committee, and all participants provided written informed consent prior to participation.

Conditions

• Knee Osteoarthritis
• Osteearthritis

Interventions

Type	Name	Description
OTHER	Isotonic Quadriceps Exercise Using NK Table	Isotonic knee extension exercise performed using the N-K Table device at specified load angles (0° and 50°) with resistance set at 75% of 10RM.

Timeline

• Start date: 2024-01-20
• Primary completion: 2024-06-05
• Completion: 2025-05-25
• First posted: 2026-03-06
• Last updated: 2026-03-06

Locations

1 site across 1 country: Indonesia