Trials / Completed
CompletedNCT07455708
Impact of NR3C1 rs41423247 (BclI) Polymorphism on Disease Severity in Alopecia Areata
Assessment of Glucocorticoid Receptor Gene Polymorphism in Alopecia Areata
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 120 (actual)
- Sponsor
- Benha University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response. The rs41423247 polymorphism (BclI) may influence glucocorticoid sensitivity and disease activity. This study aims to investigate the association between NR3C1 rs41423247 polymorphism and susceptibility to alopecia areata and to evaluate its correlation with disease severity using the Severity of Alopecia Tool (SALT) score.
Conditions
Timeline
- Start date
- 2023-11-01
- Primary completion
- 2024-11-01
- Completion
- 2024-12-01
- First posted
- 2026-03-06
- Last updated
- 2026-03-06
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT07455708. Inclusion in this directory is not an endorsement.