NCT07454824

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.

Conditions

• Dementia
• Potentially Inappropriate Medication Use
• Mild Cognitive Impairment (MCI)

Interventions

Type	Name	Description
OTHER	e-ALIGN Patient-Portal Deprescribing	The intervention will consist of educational materials about deprescribing, which will be sent to the patient prior to the scheduled primary care visit.

Timeline

• Start date: 2026-03-15
• Primary completion: 2026-08-01
• Completion: 2026-12-01
• First posted: 2026-03-06
• Last updated: 2026-03-06