NCT07453823

The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight

The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight: a Randomized, Double-blind, Placebo-controlled Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Chr Hansen - part of Novonesis · Industry
• Sex: All
• Age: 50 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The study is a single-center, randomized, double-blind, placebo-controlled study in middle-aged to elderly adults with excessive body weight. The study includes an 8-week intervention period followed by a 2-week follow-up period. The study will evaluate the effect of a synbiotic consisting of two probiotic strains and a prebiotic. The aim is to investigate the effect of the synbiotic on modulating the gut microbiota and improving markers of gastrointestinal permeability and integrity and gastrointestinal discomfort.

Conditions

• Gastrointestinal Microbiome (Focus)
• Gastrointestinal Symptoms

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Synbiotic	Synbiotic \- Given daily for 56 days
DIETARY_SUPPLEMENT	Placebo	Placebo \- Given daily for 56 days

Timeline

• Start date: 2026-03-18
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2026-03-06
• Last updated: 2026-04-15

Locations

1 site across 1 country: Ireland