NCT07451951

Effectiveness of SQLNS vs MQLNS for Prevention of Undernutrition in Children 6-12 Months

Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Children Aged 6-12 Months: An Individually Randomized, Parallel-Group Non-Inferiority Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 706 (estimated)
• Sponsor: Aga Khan University · Academic / Other
• Sex: All
• Age: 6 Months – 7 Months
• Healthy volunteers: Accepted

Summary

Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need from breastmilk and regular foods alone. For this reason, some children receive special nutrient supplements to support healthy growth. Lipid-based nutrient supplements (LNS) are one type of supplement that provides important vitamins and minerals. These supplements are used in many countries to help prevent undernutrition in young children. In Pakistan, the government social safety net program currently provides medium-quantity LNS to children starting at six months of age. However, it is not known whether a smaller-quantity LNS could provide similar benefits for children in this age group from under-resourced communities that have limited access to nutritious foods. The goal of this trial is to learn whether small-quantity lipid-based nutrient supplements (SQ-LNS) work as well as medium-quantity lipid-based nutrient supplements (MQ-LNS) in preventing undernutrition in children aged six to twelve months. The main questions this study aims to answer are: * Does SQ-LNS work as well as MQ-LNS in supporting healthy growth, including reducing stunting, wasting, and underweight? * Does SQ-LNS work as well as MQ-LNS in reducing anemia? Researchers will compare SQ-LNS and MQ-LNS to see if SQ-LNS is as good as MQ-LNS in preventing undernutrition. Participants will: * Receive either SQ-LNS or MQ-LNS once daily for 6 months * Have their length, weight and mid-upper arm circumference (MUAC) measured monthly * Have their blood tested for anemia at the start and end of supplementation

Conditions

• Undernutrition

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Medium-quantity lipid-based nutrient supplement (MQ-LNS)	50 g/day lipid-based nutrient supplement providing energy and essential micronutrients, administered daily for 6 months.
DIETARY_SUPPLEMENT	Small-quantity lipid-based nutrient supplement (SQ-LNS)	20 g/day lipid-based nutrient supplement providing energy and essential micronutrients, administered daily for 6 months.

Timeline

• Start date: 2026-02-16
• Primary completion: 2027-02-16
• Completion: 2027-02-16
• First posted: 2026-03-05
• Last updated: 2026-03-05

Locations

2 sites across 1 country: Pakistan