NCT07451522

Comparative Analysis of Analgesic Approaches in the Early Period After CABG

Comparative Characteristics of Analgesia Methods in the Early Postoperative Period After Coronary Artery Bypass Grafting (CABG)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Primorsky Regional General Hospital #1 · Other Government
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to study postoperative analgesia in patients undergoing CABG. And learn if tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amid) treats pain not inferiory then morphine. The main questions it aims to answer are: Does tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amid) lower the VAS score same way as a morphine? What medical problems do participants have when taking tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amid)? Participants will: Group (1)- subcutaneous single dose of morphine 10 mg would be administred based on VAS score \> 3 during 24 hours after CABG. Exprimental group (2)- subcutaneous single dose of tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amid) - 0.4 mg would be administred based on VAS score \> 3 during 24 hours after CABG. Efficacy was assessed using the VAS scale decreassion. Hemodynamic parameters and arterial blood gases were also assessed.

Conditions

• CAD - Coronary Artery Disease
• CABG
• Analgesia Assessment

Interventions

Type	Name	Description
DRUG	Tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amide)	Postoperative analgesia after CABG with tafalgin
DRUG	Morphine (+)	Postoperative analgesia wtih morphine

Timeline

• Start date: 2025-12-01
• Primary completion: 2026-03-01
• Completion: 2026-03-15
• First posted: 2026-03-05
• Last updated: 2026-03-05

Locations

1 site across 1 country: Russia