NCT07450066

Precision Lifestyle Intervention and Anthropometric, Nutritional, and Metabolic Health Outcomes

Estudio en Humanos Para la identificación de Biomarcadores de Actividad física Moderada y Sedentarismo y su Posible relación Con Determinantes genéticos e Indicadores Del Estado de Salud metabólica

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: University of the Balearic Islands · Academic / Other
• Sex: All
• Age: 25 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This clinical trial aims to recruit a core cohort of adults with normal weight, overweight, and obesity, but without other metabolic alterations, to undergo a six-month nutritional intervention. The main objective is to compare a genotype- and phenotype-based nutrition approach with a traditional nutrition plan adjusted only to phenotype. To evaluate the effectiveness of each type of intervention, anthropometric measurements and nutritional assessments will be collected at baseline, three months, and six months. In addition, plasma samples will be obtained to analyze clinical and non-clinical biomarkers, providing a more comprehensive evaluation of health status at baseline and after six months of intervention.

Conditions

• Obesity & Overweight

Interventions

Type	Name	Description
OTHER	Diet	A six-month intervention consisting of lifestyle counseling aimed at promoting adherence to a standard Mediterranean diet and providing phenotype-tailored physical activity recommendations.
OTHER	Diet	A 6-month intervention based on the Mediterranean diet with adaptations in nutritional and physical activity guidelines tailored to their genetic profile, according to the report of a commercial nutrigenetic test.

Timeline

• Start date: 2020-10-27
• Primary completion: 2024-01-30
• Completion: 2026-01-30
• First posted: 2026-03-04
• Last updated: 2026-03-04

Locations

1 site across 1 country: Spain