Trials / Recruiting
RecruitingNCT07449117
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- Sponsor
- Masaryk University · Academic / Other
- Sex
- All
- Age
- 60 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.
Detailed description
The study aims to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the deep structures of the fronto-striatal circuit involved in language processing. The research focuses on patients with neurodegenerative diseases who often suffer from communication deficits and impaired sentence comprehension. Participants will undergo a cross-over design consisting of a single session of active TIS directed at the striatum and a session of placebo stimulation. The stimulation will be administered in a randomized order. The duration of the stimulation is approximately 20 minutes. During the stimulation, participants will perform a sentence comprehension task. Resting-state fMRI measurements will be taken before and after the stimulation to evaluate offline effects on brain connectivity and potential neuroplasticity.
Conditions
- Mild Cognitive Impairment (MCI) Amnestic
- Lewy Body Disease With Mild Cognitive Impairment
- Parkinson's Disease With Mild Cognitive Impairment
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Active Temporal Interference Stimulation (TIS) | Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task. |
| DEVICE | Placebo / Sham TIS | Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task. |
Timeline
- Start date
- 2026-03-01
- Primary completion
- 2027-12-01
- Completion
- 2028-12-01
- First posted
- 2026-03-04
- Last updated
- 2026-03-04
Locations
1 site across 1 country: Czechia
Source: ClinicalTrials.gov record NCT07449117. Inclusion in this directory is not an endorsement.