NCT07449052

Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease

Inclusive Invasive Physiological Assessment in Angina Syndromes - Obstructive Coronary Artery Disease

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 450 (estimated)
• Sponsor: UMC Utrecht · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention. The main question it aims to answer is: Does performing coronary function testing in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention lead to better relieve of angina symptoms and improvement in quality of life? Researchers will compare this group undergoing coronary function testing with a control group who will solely undergo percutaneous coronary intervention. Participants will: * Undergo percutaneous coronary intervention and coronary function testing in the intervention arm * Undergo percutaneous coronary intervention in the control arm

Conditions

• Coronary Artery Disease (CAD)
• Obstructive Coronary Artery Disease
• Coronary Microvascular Dysfunction (CMD)
• Vasospasm, Coronary
• Stable Angina Pectoris

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Coronary function testing	Coronary function testing to test for coronary microvascular dysfunction and coronary vasospasm
PROCEDURE	Percutaneous coronary intervention	Percutaneous coronary intervention performed according to local practice standards and guidelines

Timeline

• Start date: 2026-03-01
• Primary completion: 2028-10-01
• Completion: 2029-03-01
• First posted: 2026-03-04
• Last updated: 2026-03-04