NCT07446712

Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome

Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome: a Randomised Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University Hospital Ostrava · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to investigate the efficacy of hyperbaric oxygen therapy as an adjunct in the management of severe complex regional pain syndrome.

Detailed description

Randomised controlled trial (RCT) with delayed start of therapy (delayed-start / wait-list). The intervention (early) group initiates therapy immediately after baseline (T0). The control (delayed) group initiates therapy only after the first follow-up (T1). The primary inter-group comparison is planned at time T1 (4-6 weeks after T0). In addition, for the delayed group, the post-treatment evaluation of T2 (4-6 weeks after T1) is supportive of the effect.

Conditions

• Chronic Pain
• Complex Regional Pain Syndrome

Interventions

Type	Name	Description
PROCEDURE	Early hyperbaric oxygen therapy (HBOT)	The hyperbaric oxygen therapy (HBOT) will be initiated immediately after enrolment
PROCEDURE	Delayed hyperbaric oxygen therapy (HBOT)	The hyperbaric oxygen therapy (HBOT) will be initiated 4-6 weeks after enrolment.

Timeline

• Start date: 2026-04-01
• Primary completion: 2028-04-01
• Completion: 2029-04-01
• First posted: 2026-03-03
• Last updated: 2026-03-03

Locations

2 sites across 1 country: Czechia