NCT07446569

Perception and Integration of Sensory Information in the Early Stages of Psychosis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 294 (estimated)
• Sponsor: Centre Psychothérapique de Nancy · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are: * Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk? * How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits? Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis. Participants will: * Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task. * Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials). * Provide demographic, clinical, and neuropsychological data during study visits. * For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.

Conditions

• Early Psychosis
• Schizophrenia Prodromal

Interventions

Type	Name	Description
BEHAVIORAL	behavioral tasks	All participants will undergo behavioral assessments of visual and auditory processing, including contrast sensitivity, facial emotion recognition, visual inference using Necker cubes, tone-matching, and auditory emotion recognition.
DEVICE	Electroretinography	Participants will additionally undergo electrophysiological recordings of retinal function (a-wave, b-wave, phNR, oscillatory potentials) using flash stimulation.
DIAGNOSTIC_TEST	Comprehensive Assessment of At Risk Mental States (CAARMS)	All participants will be assessed using the CAARMS in order to evaluate their symptoms and classify them into either the CHR or FEP group
BEHAVIORAL	Neuropsychological tests	TAP attention and working memory test, fNART, VOSP, Verbal fluency test.

Timeline

• Start date: 2026-04-01
• Primary completion: 2028-04-01
• Completion: 2028-11-01
• First posted: 2026-03-03
• Last updated: 2026-03-03

Locations

4 sites across 1 country: France