NCT07445724

Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery

Evaluation of Soft Tissue Healing and Microbiological Status in Patients Undergoing Surgical Extraction of Impacted Mandibular Third Molars Using Cyanoacrylate Adhesive

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (estimated)
• Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this randomized clinical trial is to evaluate whether cyanoacrylate tissue adhesive can improve postoperative outcomes compared with conventional silk sutures in patients undergoing surgical removal of impacted mandibular third molars. The main questions it aims to answer is: Is there a difference in wound healing support, soft-tissue conditions, and microbiological outcomes at the surgical site of impacted mandibular third molar extraction between closure with conventional sutures and cyanoacrylate tissue adhesive? Researchers will compare cyanoacrylate tissue adhesive with conventional silk sutures to determine whether the adhesive provides superior postoperative recovery and periodontal outcomes. Participants will: * Undergo surgical extraction of an impacted mandibular third molar. * Receive wound closure using either cyanoacrylate tissue adhesive or conventional silk sutures. * Be followed postoperatively for assessment of pain, swelling, trismus, soft-tissue healing, and periodontal measurements at specified time points.

Detailed description

Surgical removal of impacted mandibular third molars is one of the most common procedures in dental practice. Following surgery, conventional wound closure using sutures is widely employed to support healing. However, this method has several limitations, including difficult surgical access to the posterior oral cavity, tissue trauma during suturing, plaque accumulation around the suture site, and the need for suture removal after surgery. These drawbacks create a need for alternative wound-closure approaches. Recently, the development of biomaterials, particularly cyanoacrylate tissue adhesives has introduced a new strategy that may improve healing and reduce postoperative complications. Cyanoacrylate tissue adhesives have been reported to possess favorable biological properties, including antibacterial activity, hemostatic capability, biodegradability, and biocompatibility with living tissues. Various cyanoacrylate derivatives have been investigated, ranging from methyl, ethyl, and propyl to butyl and octyl cyanoacrylate, among which butyl and octyl forms demonstrate the most favorable clinical performance. In oral surgery, cyanoacrylate has been recognized as a useful alternative due to its ability to shorten operative time, reduce postoperative pain, and eliminate the need for suture removal after healing. Lascaz Netto and Macedo (1986) evaluated wound healing in patients using cyanoacrylate for gingival graft fixation and reported significantly reduced surgical time with normal postoperative recovery. Cyanoacrylate adhesives have also been applied for multiple clinical purposes, including periodontal dressing, closure of sinus membrane perforations, fixation of bone fragments in fracture surgery, and peripheral nerve repair. In addition, cyanoacrylate has been proposed for wound closure via primary healing and, more recently, for protection of wounds healing by secondary intention. Although cyanoacrylate tissue adhesives have been widely studied and applied in medicine, limited evidence exists regarding their effectiveness in supporting soft-tissue healing and their impact on the local oral microbiological environment. Moreover, few studies have directly compared tissue adhesives with conventional suturing across multiple bacterial species using modern analytical techniques. Therefore, this study was conducted to evaluate the soft-tissue healing support provided by cyanoacrylate tissue adhesive compared with traditional sutures through three aspects: common postoperative complications (pain, swelling, and trismus), the rate of soft-tissue healing, and changes in the microbiological profile at the surgical site.

Conditions

• Impacted Mandibular Third Molar

Interventions

Type	Name	Description
PROCEDURE	cyanoacrylate tissue adhesive	Following surgical removal of the impacted mandibular third molar, wound closure is achieved by applying cyanoacrylate tissue adhesive along the mucosal margins to approximate the soft tissues without suturing. The adhesive is allowed to polymerize according to the manufacturer's instructions. No sutures are placed at the surgical site. Postoperative care is standardized across study conditions.
PROCEDURE	Silk Sutures	After surgical removal of the impacted mandibular third molar, wound closure is performed using interrupted non-resorbable silk sutures to approximate the mucosal margins. Sutures are removed at the routine postoperative follow-up visit. Postoperative care is identical to that provided in the cyanoacrylate condition.

Timeline

• Start date: 2026-03-01
• Primary completion: 2026-09-01
• Completion: 2026-12-01
• First posted: 2026-03-03
• Last updated: 2026-03-03