NCT07445633

The Ability of Brain Waves Activity to Detect Patient Susceptibility to Post-Operative Pain

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This observational study evaluates whether resting-state EEG alpha activity can help identify endodontic patients at higher risk of post-operative pain following single-visit root canal treatment. EEG will be recorded before treatment and pain intensity will be self-reported using a Visual Analogue Scale (VAS) during the early post-treatment period.

Detailed description

This observational clinical study is designed to examine the association between resting-state electroencephalography (EEG) alpha activity and the intensity of post-operative pain following single-visit root canal treatment. Participants will be recruited from an endodontic clinic after ethics committee approval. Resting-state EEG will be recorded using a wearable EEG system prior to treatment. Post-operative pain intensity will be assessed using a patient-reported Visual Analogue Scale (VAS) during the early post-treatment period. Participants will be classified based on baseline alpha activity (e.g., lower versus higher alpha power range). Analyses will evaluate whether baseline EEG alpha measures are associated with subsequent pain ratings and whether differences in alpha activity relate to higher post-operative pain susceptibility. The goal is to determine whether EEG alpha activity may serve as a practical biomarker for post-endodontic pain susceptibility.

Conditions

• Pulp Disease, Dental

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Detection of th alpha brain waves activity	The study utilizes the EMOTIV® EPOC X, a mobile, wireless 14-channel EEG headset. This differs from traditional clinical EEG setups that often require bulky, wired equipment and the application of messy conductive gels, making this method much more suitable for a chair-side dental environment.

Timeline

• Start date: 2022-01-01
• Primary completion: 2025-03-01
• Completion: 2025-07-01
• First posted: 2026-03-03
• Last updated: 2026-03-03

Locations

1 site across 1 country: Egypt

Regulatory

• FDA-regulated device study