NCT07445230

Serum Bicarbonate Changes During Laparoscopic Bariatric Surgery

Metabolic Effects of Pneumoperitoneum During Laparoscopic Bariatric Surgery: Association Between Perioperative Serum Bicarbonate Change and Early Discharge Readiness

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 85 (estimated)
• Sponsor: Istinye University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Pneumoperitoneum during laparoscopic bariatric surgery induces carbon dioxide absorption and may lead to perioperative alterations in acid-base balance. Serum bicarbonate (HCO₃-) plays a central role in metabolic compensation; however, the clinical relevance of perioperative bicarbonate changes remains insufficiently defined. This prospective observational study aims to evaluate the association between pneumoperitoneum duration and perioperative serum bicarbonate change (ΔHCO₃-), and to investigate whether ΔHCO₃- is associated with early discharge readiness at 48 hours (DR-48) following laparoscopic bariatric surgery. Patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass will be enrolled consecutively. No alteration of routine clinical care will occur.

Conditions

• Acid Base Disorder

Interventions

Type	Name	Description
OTHER	Laparoscopic Bariatric Surgery	Standard-of-care laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) performed according to institutional protocols. No experimental intervention is introduced. The study prospectively observes perioperative serum bicarbonate changes and their association with pneumoperitoneum duration and early discharge readiness.

Timeline

• Start date: 2026-03-01
• Primary completion: 2026-04-30
• Completion: 2026-05-15
• First posted: 2026-03-03
• Last updated: 2026-03-03

Locations

1 site across 1 country: Turkey (Türkiye)