NCT07445217

Predictive Validity of the Personal and Social Performance Scale for PANSS Outcomes in Schizophrenia

Predictive Validity of the Personal and Social Performance Scale for PANSS Outcomes in Schizophrenia: a Severity-stratified Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 763 (actual)
• Sponsor: Calo Psychiatric Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The Positive and Negative Syndrome Scale (PANSS) is a widely used instrument for assessing symptom severity in schizophrenia, whereas the Personal and Social Performance Scale (PSP) provides a practical measure of functional outcomes. This study aimed to evaluate the predictive validity of the PSP for PANSS outcomes in individuals with schizophrenia. A total of 763 patients diagnosed with schizophrenia and receiving paliperidone treatment were recruited in a 12-week multicenter prospective study. Among participants with a baseline PANSS score greater than 90, those with a 12-week PSP score above 60 were more likely to achieve a reduction of more than 20% in PANSS scores, whereas those with a PSP score below 60 showed less improvement.

Detailed description

This study employed a 12-week, multicenter, prospective research design focusing on the administration of the antipsychotic medication paliperidone. Assessments were conducted at baseline, week 4, and week 12. Two widely used scales-the PANSS and PSP-were utilized to evaluate patients before and after treatment, followed by a correlation analysis of the results.

Conditions

• Functional Outcomes

Interventions

Type	Name	Description
DRUG	This study employed a 12-week, multicenter, prospective research design focusing on the administration of the antipsychotic medication paliperidone.	Assessments were conducted at baseline, week 4, and week 12. Two widely used scales-the PANSS and PSP-were utilized to evaluate patients before and after treatment, followed by a correlation analysis of the results.

Timeline

• Start date: 2008-03-10
• Primary completion: 2008-06-01
• Completion: 2008-09-04
• First posted: 2026-03-03
• Last updated: 2026-03-03

Locations

1 site across 1 country: Taiwan