NCT07444294

A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults

A Phase 1 Single- and Multiple-Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SRK-439 in Healthy Adults

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 76 (estimated)
• Sponsor: Scholar Rock, Inc. · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

A phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of SRK-439 in healthy adults

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Placebo	Matching placebo to SRK-439, subcutaneous administration
DRUG	SRK-439	Single ascending dose, subcutaneous administration
DRUG	SRK-439	Multiple ascending dose, subcutaneous administration

Timeline

• Start date: 2025-11-21
• Primary completion: 2026-12-17
• Completion: 2027-06-09
• First posted: 2026-03-02
• Last updated: 2026-03-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study