Trials / Completed
CompletedNCT07443566
10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology
10-Year Follow-up of Mortality in Patients With Acute Hip Fractures: Associations With Pre-Alzheimer's/Alzheimer's Disease and Cerebrospinal Fluid Biomarkers
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 404 (actual)
- Sponsor
- Bengt Nellgård · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Not accepted
Summary
This study is a 10-year follow-up of a previously enrolled cohort of patients who underwent surgery for acute hip fracture with spinal anesthesia and had pre-fracture cognitive status assessed (Clinical Dementia Rating, CDR) and cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease measured (e.g., Aβ42/Aβ40 ratio, total tau, phosphorylated tau). The primary aim is to determine long-term survival at 10 years after index hip fracture surgery and to evaluate whether baseline cognitive status and/or Alzheimer-type CSF biomarker profiles are associated with long-term mortality.
Detailed description
Participants were originally included during admission for acute hip fracture (October 2013-June 2015) at Sahlgrenska University Hospital, Mölndal, Sweden, and underwent lumbar CSF sampling at spinal anesthesia induction. Cognitive status prior to the fracture was assessed using CDR. Mortality will be ascertained through Swedish national registries. The follow-up extends survival assessment to approximately 10 years after surgery. Analyses will compare survival across baseline cognitive status categories and biomarker-defined groups (e.g., normal vs abnormal Aβ42/Aβ40 ratio), and may adjust for baseline covariates (e.g., age, sex, ASA class / hip fracture risk scores if available from original dataset).
Conditions
Timeline
- Start date
- 2013-10-01
- Primary completion
- 2015-06-01
- Completion
- 2015-06-01
- First posted
- 2026-03-02
- Last updated
- 2026-03-02
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT07443566. Inclusion in this directory is not an endorsement.