NCT07440121

Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection

The Effect of Different Fluid Therapy on Major Postoperative Morbidity in Patients Undergoing Non-donor Hepatectomy: a Pilot Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Zhihong LU · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss. However, fluid restriction may lead to inadequate perfusion of vital organs and even contribute to postoperative organ dysfunction, such as acute kidney injury (AKI). Therefore, this study aims to compare the effects of restrictive versus liberal fluid therapy on major complications following hepatectomy.

Conditions

• Anesthesia
• Surgery

Interventions

Type	Name	Description
OTHER	restrictive fluid infusion	Fluid infusion is restricted at 2 ml·kg- 1·h- 1 from the moment the patient arrive in the operating room to immediately after the liver lesions are removed
OTHER	preload	6 ml·kg- 1·h- 1 of hydroxyethyl starch solution is infused before anesthesia
OTHER	nitro	Nitroglycerin is infused from start of anesthesia to immediately after the liver lesions are removed.The starting infusion rates of nitroglycerin is 0.5 μg·kg- 1·min- 1 . If the speed of administration requires adjustment, nitroglycerin is added or decreased by 0.1 μg·kg- 1·min- 1.

Timeline

• Start date: 2026-04-02
• Primary completion: 2026-12-02
• Completion: 2027-02-02
• First posted: 2026-02-27
• Last updated: 2026-02-27