Trials / Completed
CompletedNCT07439068
A-PRF and CGF in Palatal Donor Site Healing
Effects on Patients' Postoperative Morbidity and Donor Site Wound Healing of A-PRF and CGF Application After Free Gingival Graft Harvesting: A Comparative Randomized Clinical Trial
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 45 (actual)
- Sponsor
- Ordu University · Academic / Other
- Sex
- All
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Not accepted
Summary
The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.
Detailed description
The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting. Fourty-five patients who underwent FGG harvesting were randomly assigned to three groups: (1) control group (n=15), receiving only a sterile gelatin sponge; (2) A-PRF group (n=15), receiving A-PRF clot membranes; and (3) CGF group (n=15), receiving CGF clot membranes at the donor site. The epithelization rate, color match, and sensation scores of the palatal wound were assessed at 1, 2, 3, and 4 weeks postoperatively. Pain levels, analgesic consumption, and bleeding time were self-reported by patients for the first 7 days of healing.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Advanced platelet-rich fibrin | Advanced platelet-rich fibrin membranes and free gingival graft |
| PROCEDURE | Concentrated growth factor | Concentrated growth factor membranes and free gingival graft |
| PROCEDURE | Sterile gelatin sponge | Sterile gelatin sponge and free gingival graft |
Timeline
- Start date
- 2020-11-01
- Primary completion
- 2022-05-30
- Completion
- 2022-05-31
- First posted
- 2026-02-27
- Last updated
- 2026-02-27
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT07439068. Inclusion in this directory is not an endorsement.