NCT07437430

Evaluation of Food Additive Contributions to Obesity: Pilot Study 1

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time administration of K sorbate versus placebo after participants reduce the background consumption of related food additives.

Conditions

• Obesity (Disorder)

Interventions

Type	Name	Description
OTHER	Potassium sorbate one-time administration followed by washout then placebo one-time administration	K sorbate 450 mg will be administered with breakfast during testing session 1, followed by a minimum of 2-week washout and then placebo administration with breakfast during testing session 2
OTHER	Placebo one-time administration followed by washout then potassium sorbate one-time administration	Placebo will be administered with breakfast during testing session 1, followed by a minimum of 2-week washout and then K sorbate 450 mg administration with breakfast during testing session 2

Timeline

• Start date: 2026-02-10
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2026-02-27
• Last updated: 2026-02-27

Locations

1 site across 1 country: Canada