NCT07435857

Effects of Exercise During Pregnancy on the Long-term Metabolic Health of Mothers and Their Offspring

Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers and Their Offspring: An 8- to 10-year Follow-Up Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 221 (actual)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of this study was to assess the long-term metabolic effects of gestational exercise on overweight and obese women and their offspring 8-10 years post-intervention.

Detailed description

We conducted a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent comprehensive metabolic evaluations, including anthropometric measurements (weight, skinfold thickness, and body composition), blood pressure assessment, oral glucose tolerance tests (OGTTs), insulin release tests (IRTs), and lipid profiling.

Conditions

• Metabolic Health

Interventions

Type	Name	Description
BEHAVIORAL	exercise	The present study is a prospective follow-up of a randomized controlled trial (RCT) that was conducted in the Department of Obstetrics and Gynecology, Peking University First Hospital, from December 2014 to April 2017. In this RCT, 300 obese/overweight pregnant women (prepregnancy BMI ≥24 kg/m²) at \<12+6 weeks of gestation were randomized to exercise (n=150) and control groups (n=150), and the efficacy of regular exercise in early pregnancy to prevent GDM among overweight/obese pregnant Chinese women was investigated. The patients allocated to the exercise group were assigned to a cycling program (3 times per week, at least 30 min/session, rating of perceived exertion 12-14); the program was initiated within 3 days of randomization and continued until 37 weeks of gestation. The patients in the control group maintained their usual daily activities. The original RCT has been reported previously （Wang, C.Am. J. Obstet. Gynecol. 2017, 216 (4), 340-351.)

Timeline

• Start date: 2024-06-01
• Primary completion: 2024-11-15
• Completion: 2024-11-15
• First posted: 2026-02-27
• Last updated: 2026-02-27

Locations

1 site across 1 country: China