NCT07434362

Serum Endocan, Alarin, and Galanin-Like Peptide Levels in Diabetic Retinopathy

Association of Serum Endocan, Alarin, and Galanin-Like Peptide Levels With Diabetic Retinopathy Stages and Optical Coherence Tomography (OCT) Findings

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Elazıg Fethi Sekin Sehir Hastanesi · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This prospective cross-sectional study aims to evaluate the association between serum endocan, alarin, and galanin-like peptide levels and the stages of diabetic retinopathy (DR), as well as their relationship with optical coherence tomography (OCT) findings. A total of 120 participants will be included: 30 patients without diabetic retinopathy, 30 with non-proliferative diabetic retinopathy, 30 with proliferative diabetic retinopathy, and 30 healthy control subjects. In addition to routine preoperative blood sampling, an additional 5 mL of venous blood will be collected for biomarker analysis using ELISA. Macular and peripapillary retinal nerve fiber layer measurements will be obtained using OCT. Serum biomarker levels will be compared across DR stages and analyzed for correlation with OCT parameters.

Conditions

• Diabetic Retinopathy
• Diabetes Mellitus
• Retinal Microvascular Disease

Interventions

Type	Name	Description
PROCEDURE	Venous Blood Sampling	Collection of 5 mL of venous blood in addition to routine preoperative sampling for the measurement of serum endocan, alarin, and galanin-like peptide levels using ELISA.
PROCEDURE	Optical Coherence Tomography (OCT)	Non-invasive optical coherence tomography imaging of the macula and peripapillary retinal nerve fiber layer using a Canon OCT device for structural retinal assessment.

Timeline

• Start date: 2026-01-30
• Primary completion: 2026-02-01
• Completion: 2026-02-18
• First posted: 2026-02-25
• Last updated: 2026-02-25

Locations

1 site across 1 country: Turkey (Türkiye)