NCT07434141

Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers

Comparative Analysis of Postoperative Pain in Symptomatic Irreversible Pulpitis Teeth Following Single Cone Obturation Using Three Different Sealers: A Randomized Clinical Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Tehran University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare post-treatment pain after root canal therapy in adults with irreversible pulpitis using different root canal sealers. The study will also evaluate the need for pain medication after treatment. The main questions this study aims to answer are: Does the type of root canal sealer affect the intensity of pain after treatment? Does the type of sealer influence the number of analgesic tablets taken by participants? How does pain change over time after treatment with different sealers? Researchers will compare two bioceramic sealers (EndoSeal TCS and NeoSeal) with a resin-based sealer (AH Plus) to determine their effects on post-endodontic pain. Participants will: Receive root canal treatment using one of the study sealers Report their pain intensity at specific time points after treatment Record the number of analgesic tablets taken during the follow-up period

Conditions

• Symptomatic Irreversible Pulpitis (SIP)
• Symptomatic Irreversible Pulpitis With Apical Peridontitis

Interventions

Type	Name	Description
PROCEDURE	Endoseal TCS	Bioceramic, premixed calcium silicate-based root canal sealer used for obturation with the single-cone technique during root canal treatment
PROCEDURE	Neosealer	Fast-setting calcium silicate-based bioceramic root canal sealer used for obturation with the single-cone technique during root canal treatment
PROCEDURE	AH Plus	Epoxy resin-based root canal sealer used for obturation with the single-cone technique during root canal treatment

Timeline

• Start date: 2025-06-08
• Primary completion: 2026-04-01
• Completion: 2026-05-30
• First posted: 2026-02-25
• Last updated: 2026-02-25

Locations

1 site across 1 country: Iran