NCT07433829

Prefrontal Neuroplasticity and Coping Strategies in Healthy Population

Prefrontal Neuroplasticity and Coping Strategies in Healthy Population: a Randomized Sham Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: The Hong Kong Polytechnic University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.

Conditions

• Health Adult Subjects

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation	sham stimulation protocols is to mimic the sensations experienced by participants during active stimulation, without stimulating the brain

Timeline

• Start date: 2026-01-17
• Primary completion: 2026-03-30
• Completion: 2026-03-30
• First posted: 2026-02-25
• Last updated: 2026-04-02

Locations

1 site across 1 country: China