NCT07432685

Kinematics-Based Prediction of Chronic Pain After Combat-Related Extremity Trauma

KIN-LIMB Protocol V1.0. KIN-LIMB: Kinematics-Based Prediction of Chronic Pain After Combat-Related Extremity Trauma

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Combat-related extremity trauma frequently results in persistent pain, including neuropathic, residual limb, and phantom limb pain. The kinematics of injury-including energy level, direction of force, and dominant force components-may independently predict tissue deformation, nerve stress, and the transition from acute to chronic- pain. This prospective observational cohort study will assess whether kinematics-only variables predict chronic pain outcomes after combat-related upper and lower limb injuries. Pain outcomes will include pain intensity, pain extent (surface/area), neuropathic pain features, and mechanical pain sensitivity measured using von Frey filaments.

Detailed description

Adults with combat-related limb trauma will be enrolled within 72 hours of injury. Baseline assessment will include a standardized kinematics classification documenting (1) energy class, (2) dominant direction of force, (3) dominant force component, and (4) kinematics severity grade (K0-K3). Participants will be followed at 6 weeks, 3 months, and 6 months. The primary endpoint is chronic limb pain at 3 months. Secondary endpoints include chronic pain at 6 months, pain area, neuropathic features, and mechanical pain thresholds using von Frey testing at standardized limb sites (injured and contralateral control). This is a non-interventional study; no treatment decisions are dictated by the protocol.

Conditions

• Residual Limb Pain
• Post-Traumatic Limb Pain
• Extremity Trauma
• Combat-Related Limb Injury
• Phantom Limb Pain
• Phantom Limb Pain After Amputation
• Chronic Pain Due to Injury
• Chronic Pain

Timeline

• Start date: 2026-03-12
• Primary completion: 2026-12-22
• Completion: 2027-12-14
• First posted: 2026-02-25
• Last updated: 2026-02-25

Locations

1 site across 1 country: Ukraine