NCT07432581

Topical Insulin Dressing on Management of Diabetic Foot Ulcers

Topical Insulin Dressing on Management of Diabetic Foot Ulcers, Would it Help?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to find out the advantages of topical insulin in the management of diabetic foot ulcers over the conventional wound saline dressing.

Detailed description

Non healing foot ulcers constitute a major problem that plagues those with diabetes due to angiopathy and neuropathy. It is well known that the basic cellular and molecular mechanisms that result in wound healing involve cell adhesion, migration, proliferation, differentiation, and apoptosis. The molecular mechanisms of insulin signaling and its metabolic effects have been well studied in its classical target tissues. Insulin stimulates the growth and development of different cell types and affects proliferation, migration, and secretion by keratinocytes, endothelial cells, and fibroblasts.

Conditions

• Topical
• Insulin
• Dressing
• Diabetic Foot Ulcers

Interventions

Type	Name	Description
DRUG	Insulin	The ulcers were cleaned with normal saline and then irrigated with 4 units (0.1 ml) of human soluble insulin (Actrapid) in 1 ml normal saline (0.9%) for every 10 cm square of the wound.
DRUG	Normal saline	The ulcers were cleaned with normal saline without insulin and covered with sterile cotton gauzes

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-01-01
• Completion: 2024-01-01
• First posted: 2026-02-25
• Last updated: 2026-02-25

Locations

1 site across 1 country: Egypt