NCT07430852

Inherited and Environmental Risks Acting on Body Weight

Genetic and Environmental Contributions to Obesity Pathogenesis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (estimated)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.

Detailed description

In study 1, participant twin pairs that differ in habitual diet intake, will complete an in-person study visit that includes an MRI of the brain and abdomen, body composition measurement, a blood draw and questionnaires. In study 2, a different set of participant twin pairs will complete 3 in-person study visits over 2 weeks, during which all meals will be provided by the study. Visits will include brain MRI, body composition measurements, blood draws and questionnaires.

Conditions

• Genetics
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Diet modification	Participants will be provided all meals for a 14-day period. For 7 of the days, meals will be 150% of estimated daily caloric needs and for the other 7 days, meals will be low in calories, consistent with recommendations for weight loss.

Timeline

• Start date: 2026-09-01
• Primary completion: 2029-11-01
• Completion: 2030-04-30
• First posted: 2026-02-24
• Last updated: 2026-02-24

Locations

1 site across 1 country: United States