NCT07430228

Efficacy of Intravenous Oxytocin to Speed Recovery After THA

Efficacy of Intravenous Oxytocin to Speed Recovery After Total Hip Arthroplasty

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to test whether perioperative intravenous (IV) oxytocin compared to placebo results in faster recovery in disability as measured by daily steps over 56 days after Total Hip Arthroplasty (THA).

Detailed description

This is a single center, NIH funded clinical study at Atrium Health Wake Forest Baptist Medical Center. The investigators will utilize a triple-masked, parallel group, randomized design to compare intravenous (IV) oxytocin to placebo to determine IV oxytocin's actions on speed of recovery from physical disability and postoperative pain after Total Hip Arthroplasty (THA).

Conditions

• Total Hip Arthroplasty

Interventions

Type	Name	Description
DRUG	intravenous administration of oxytocin	Single administration of oxytocin 26 micrograms administered intravenously over a period of 45 minutes.
DRUG	Placebo	Saline will be administered intravenously over a period of 45 minutes

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-06-01
• Completion: 2027-06-01
• First posted: 2026-02-24
• Last updated: 2026-03-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study