NCT07429370

The Effects of One Day of Activity on the Next Day's Exercise Response

A Single Day of Inactivity on the Systemic Metabolic and Inflammatory Exercise Response

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (estimated)
• Sponsor: Concordia University Wisconsin · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.

Detailed description

Previous work demonstrated a greater utilization of carbohydrates (CHO) at the end of aerobic exercise with a day of reduced activity (\<5,000 steps). Additionally, there are differences in the RNA profile at rest and during exercise in pathways related to inflammation, metabolism, and innate immunity that warrant further research. Together, these data highlight that a single day of reduced activity alters systemic homeostasis that affects the exercise response. Given the potency of exercise to ameliorate risk of cardiovascular disease, more research is needed to find factors to augment the exercise response. Therefore, this study has two goals: 1) Analyze circulating metabolomics, and 2) metabolomics and proteomics in response to exercise after a day of reduced activity.

Conditions

• Inactivity, Physical

Interventions

Type	Name	Description
BEHAVIORAL	Decreased step count	Subjects will walk less than 5,000 steps

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2026-02-24
• Last updated: 2026-02-24

Locations

1 site across 1 country: United States