NCT07429292

SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

SPARK Study - Sympathetic PeriArterial Radial blocK Study

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.

Conditions

• Healthy Volunteers
• Sympathetic Activity

Interventions

Type	Name	Description
DRUG	Lidocaine 2%	Small-volume injection (5 mL) of 2% lidocaine around radial artery under ultrasound guidance.

Timeline

• Start date: 2026-05-01
• Primary completion: 2026-12-01
• Completion: 2027-04-01
• First posted: 2026-02-24
• Last updated: 2026-04-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study