NCT07427615

Regenerative Endodontics of Immature Teeth in Multiple Visits Versus Single Visit

Regenerative Endodontics of Immature Teeth in Multiple Visits Versus Single Visit Using LASER Activation Irrigation Technique

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Ahmed Ibrahim Salim · Academic / Other
• Sex: All
• Age: 9 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

This randomized clinical trial evaluated the clinical and radiographic outcomes of regenerative endodontic procedures performed using different irrigation activation protocols in immature permanent maxillary anterior teeth. Thirty patients were randomly assigned into three groups according to the use of laser-activated irrigation and number of visits. Clinical and cone beam computed tomographic (CBCT) outcomes were assessed over a 12-month follow-up period.

Detailed description

Thirty patients aged 9-25 years with non-vital immature permanent maxillary anterior teeth were included. Patients were randomly allocated into three equal groups based on the irrigation activation technique and number of visits. Regenerative endodontic procedures were performed following standardized protocols. Clinical evaluations were conducted at multiple follow-up intervals, while radiographic assessments using CBCT were performed at baseline, 6, and 12 months to evaluate root development and periapical healing.

Conditions

• Regenerative Endodontic Procedures

Interventions

Type	Name	Description
PROCEDURE	Regenerative Endodontic Procedure	Regenerative endodontic procedure performed using sodium hypochlorite irrigation, intracanal double antibiotic paste, platelet-rich fibrin scaffold, and bioceramic coronal barrier according to a standardized clinical protocol.
PROCEDURE	Laser-Activated Irrigation	Irrigation activation using an 810-nm diode laser with a power of 1 W, applied for three cycles of 15 seconds with 15-second intervals, performed 1 mm short of the working length.

Timeline

• Start date: 2023-03-01
• Primary completion: 2024-11-29
• Completion: 2025-11-29
• First posted: 2026-02-23
• Last updated: 2026-02-23

Locations

1 site across 1 country: Egypt