NCT07427537

Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University Hospital, Clermont-Ferrand · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy. The investigators will look at patients receiving cancer drugs known to affect the nerves, such as paclitaxel (used for lung cancer) and oxaliplatin (used for colorectal cancer).

Conditions

• Cancer, Lung
• Colon Neoplasm
• Neuropathy;Peripheral

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Assessment of blood concentrations of microRNAs	day 1, day 43, and day 155.
OTHER	Chemotherapy-induced peripheral neuropathy (CIPN) - grade	day 1, day 43, and day 155.
OTHER	Pain assessement	day 1, day 43, and day 155.
DIAGNOSTIC_TEST	Assessment of blood concentrations of neurofilament light chain	day 1, day 43, and day 155.
OTHER	Neuropathic pain assessment	day 1, day 43, and day 155.
OTHER	Chemotherapy-induced peripheral neuropathy (CIPN) - severity	day 1, day 43, and day 155.

Timeline

• Start date: 2026-01-29
• Primary completion: 2028-07-31
• Completion: 2028-07-31
• First posted: 2026-02-23
• Last updated: 2026-02-23

Locations

1 site across 1 country: France