NCT07426016

Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration

Randomized Controlled Trial of Video-Laryngoscopy Intervention or Direct Laryngoscopy for Delivery of Less Invasive Surfactant Administration for Premature Infants

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 0 Hours – 3 Days
• Healthy volunteers: Not accepted

Summary

Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?

Conditions

• Respiratory Distress Syndrome (Neonatal)
• Surfactant Deficiency Syndrome Neonatal

Interventions

Type	Name	Description
PROCEDURE	Video Laryngoscopy	Video Laryngoscopy will be used to visualize the vocal cords and place the LISA catheter
PROCEDURE	Direct Laryngoscopy	Direct Laryngoscopy will be used to visualize the vocal cords and place the LISA catheter

Timeline

• Start date: 2026-04-01
• Primary completion: 2028-04-01
• Completion: 2028-09-01
• First posted: 2026-02-23
• Last updated: 2026-02-23

Locations

1 site across 1 country: United States