NCT07425730

Early Myocardial Dysfunction Helps Identify Severe Refractory Pediatric Lupus

Myocardial Dysfunction in Pediatric Lupus

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 7 Years – 17 Years
• Healthy volunteers: Accepted

Summary

To investigate biomarkers to identify pediatric SR-SLE patients by non-invasive echocardiographic techniques.

Detailed description

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Although therapeutic advances have improved outcomes, a significant subset remains with severe disease activity despite optimal therapy, which is recognized as the severe refractory SLE (SR-SLE).A recent study using advanced echocardiographic techniques of global longitudinal strain (GLS) have revealed that left ventricular dysfunction is common in SLE patients and correlates with disease severity.The finding underscores the potential role of early myocardial dysfunction as a phenotypic marker of SR-SLE.To our knowledge, there are no validated biomarkers to reliably identify patients with SR-SLE at an early stage, especially in the pediatric population. Therefore, this study aimed to investigate biomarkers to identify pediatric SR-SLE patients.

Conditions

• Systemic Lupus Erythematosus (SLE)

Timeline

• Start date: 2026-02-01
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2026-02-23
• Last updated: 2026-02-23

Locations

1 site across 1 country: China