NCT07424989

Antibiotic Therapies for Urinary Tract Infections and Their Impact on the Gut Microbiota

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 61 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A urinary tract infection requires antibiotic treatment. While this treatment is intended to eliminate bacteria from the urine, it may also facilitate the development of resistant strains in the digestive tract. Patients are asked to provide stool samples on several occasions so that any potential side effects of this treatment on the digestive flora can be analysed.

Detailed description

Each of us has billions of bacteria in our intestines that aid digestion (scientifically known as the gut microbiota), some of which can "mutate", i.e. adapt to resist antibiotics. Although this is usually harmless, these bacteria can sometimes cause infections. Hence the importance of better understanding this phenomenon, known as the 'collateral effect on flora of otherwise beneficial antibiotic treatment'. The investigators already know that not all antibiotics are equivalent, with some having a stronger 'collateral effect'. However, the risk classification remains poorly understood. Recent advances in laboratory stool analysis now make it possible to better analyse this phenomenon. The ultimate goal is to identify treatment regimens that are both highly effective in treating urinary tract infections and have the least possible ecological impact.

Conditions

• Urinary Tract Infection(UTI)

Timeline

• Start date: 2021-07-04
• Primary completion: 2025-05-28
• Completion: 2025-05-28
• First posted: 2026-02-20
• Last updated: 2026-02-24

Locations

1 site across 1 country: France