NCT07424300

Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy

Bidirectional Relationship Between Oral Malodor And Olfactory Function In Generalized Periodontitis: A Prospective Cohort Study Evaluating Changes After Nonsurgical Periodontal Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 101 (actual)
• Sponsor: Batman University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis. A total of 101 patients were evaluated before and after routine nonsurgical periodontal therapy. Volatile sulfur compound (VSC) levels and psychophysical olfactory performance using the Sniffin' Sticks test (TDI score) were measured at baseline and one week after completion of three sessions of scaling and root planing (SRP). The study aimed to determine whether reduction of oral inflammation and halitosis is associated with improvement in olfactory performance.

Detailed description

Generalized periodontitis is a chronic inflammatory disease associated with increased production of volatile sulfur compounds (VSCs), contributing to halitosis. Elevated intraoral malodor may interfere with olfactory perception through masking effects and inflammatory mechanisms. Participants diagnosed with generalized periodontitis and complaining of halitosis underwent routine nonsurgical periodontal therapy consisting of three sessions of scaling and root planing performed at one-week intervals. Olfactory function (threshold, discrimination, identification; total TDI score) and total VSC concentrations were assessed at baseline (prior to first session) and one week after completion of the third session. The study evaluated changes in chemosensory function and halitosis parameters following periodontal therapy and analyzed correlations between baseline VSC levels and olfactory performance.

Conditions

• Periodontitis
• Olfactory Dysfunction
• Halitosis

Timeline

• Start date: 2024-12-03
• Primary completion: 2025-03-20
• Completion: 2025-03-20
• First posted: 2026-02-20
• Last updated: 2026-02-25

Locations

1 site across 1 country: Turkey (Türkiye)