Trials / Not Yet Recruiting
Not Yet RecruitingNCT07424170
The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults
Association of the Exercise-Irisin-EEG Cascade With Intrinsic Brain Vulnerability and Its Impact on Postoperative Delirium in Elderly Patients: A Prospective Cohort Study
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 140 (estimated)
- Sponsor
- Peking University People's Hospital · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Accepted
Summary
The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Preoperative physical activity level | Before the surgery, the activity levels of the participants over the past week were assessed using the Physical Activity Scale for the Elderly (PASE). |
Timeline
- Start date
- 2026-03-15
- Primary completion
- 2026-12-26
- Completion
- 2026-12-31
- First posted
- 2026-02-20
- Last updated
- 2026-03-10
Source: ClinicalTrials.gov record NCT07424170. Inclusion in this directory is not an endorsement.