NCT07423663

Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions

Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions :A Randomized Controlled Clinical Trial

• Status: Active Not Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Suez Canal University · Academic / Other
• Sex: All
• Age: 21 Years – 49 Years
• Healthy volunteers: Accepted

Summary

It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment. Given the growing concern over resistant bacterial strains, our study aims to evaluate the effectiveness of various medicaments in eliminating endodontic pathogens while minimising the risk of resistance development. By integrating microbiological analysis and clinical relevance, our research seeks to provide evidence-based recommendations for optimising intracanal disinfection protocols and improving treatment outcomes in endodontic infections.

Conditions

• Asymptomatic Apical Periodontitis

Interventions

Type	Name	Description
DRUG	Calcium Hydroxide Intracanal medication	Patients receiving CaOH (Metapaste) intracanal medication
DRUG	Calcium silicate based intracanal medication	Patients receiving Calcium silicate based (Bio-C Temp) intracanal medication
DRUG	Pectin	Patients receiving Pectin intracanal medication

Timeline

• Start date: 2024-09-01
• Primary completion: 2026-03-10
• Completion: 2026-04-01
• First posted: 2026-02-20
• Last updated: 2026-02-20

Locations

1 site across 1 country: Egypt