NCT07420231

Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the beneficial effects of the daily consumption of a synbiotic formulation-combining a prebiotic (Berberine, BBR) and a postbiotic (inactivated Bifidobacterium Longum, B.longum)-in adults experiencing intestinal discomfort.

Detailed description

This study is designed as a randomized double-blind placebo-controlled interventional study. One hundred and forty individuals aged between 18 and 75 years and experiencing a measurable level of intestinal discomfort will be randomly allocated to one of the four groups (35 subjects per group): control, prebiotic only, postbiotic only, or combination of both. Subjects will receive their assigned supplementation for 8 weeks. Intestinal discomfort will be measured through tests and questionnaires at baseline, mid-intervention (week 4), at the end of intervention (week 8), and after a follow-up period of 4 weeks (week 12).

Conditions

• Intestinal Discomfort
• Abdominal Pain/ Discomfort

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Berberine	The study foresees the intake of 3 capsules per day during 8 weeks
DIETARY_SUPPLEMENT	Bifidobacterium longum	The study foresees the intake of 3 capsules per day during 8 weeks
DIETARY_SUPPLEMENT	Bifidobacterium longum and Berberine	The study foresees the intake of 3 capsules per day during 8 weeks
DIETARY_SUPPLEMENT	Placebo	The study foresees the intake of 3 capsules per day during 8 weeks

Timeline

• Start date: 2026-02-24
• Primary completion: 2026-10-24
• Completion: 2026-12-24
• First posted: 2026-02-19
• Last updated: 2026-02-23

Locations

1 site across 1 country: Belgium