NCT07420153

Remote Ischemic Preconditioning and Postoperative Neuronal Injury

Remote Ischemic Preconditioning and Postoperative Neuronal Injury in Non-Cardiac Surgery Patients: A Randomized Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 216 (estimated)
• Sponsor: University of Hamburg-Eppendorf · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperative days, in non-cardiac surgery patients at risk for postoperative delirium.

Conditions

• Postoperative Neuronal Injury

Interventions

Type	Name	Description
OTHER	Remote ischemic preconditioning	In patients assigned to the RIPC group, we will perform RIPC on the day before surgery.
OTHER	Routine care	Patients assigned to the No-RIPC group will receive routine care and RIPC will not be performed.

Timeline

• Start date: 2026-03-02
• Primary completion: 2027-08-01
• Completion: 2027-09-01
• First posted: 2026-02-19
• Last updated: 2026-03-04

Locations

1 site across 1 country: Germany