NCT07419737

Dental Plaque Prevention Efficacy of a Stannous Fluoride Toothpaste

Dental Plaque Prevention Efficacy Evaluation and Comparison of a Stannous Fluoride Toothpaste

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 91 (actual)
• Sponsor: Church & Dwight Company, Inc. · Industry
• Sex: All
• Age: 18 Years – 69 Years
• Healthy volunteers: Accepted

Summary

This randomized, stratified, double-blind, two-cell parallel clinical study evaluated the dental plaque prevention efficacy of a stannous fluoride toothpaste compared to a sodium fluoride control toothpaste following a professional dental prophylaxis. Adult subjects brushed twice daily for 14 days with their assigned dentifrice. Plaque was assessed using the Lobene-Soparkar modification of the Turesky Modification of the Quigley-Hein Plaque Index at baseline, Day 1, and Day 14 following periods of oral hygiene abstention.

Detailed description

This two-week, randomized, double-blind, parallel-group study evaluated plaque prevention following dental cleaning. Subjects meeting plaque qualification criteria underwent a complete prophylaxis and were randomized to either a stannous fluoride test dentifrice or a sodium fluoride control dentifrice. Subjects brushed twice daily for two minutes with the assigned product. Plaque accumulation was assessed at baseline, after one day of use, and after 14 days of use following overnight abstention from oral hygiene. Plaque was disclosed and scored on facial and lingual tooth surfaces using the Lobene-Soparkar modified Turesky Plaque Index. Treatment comparisons were performed using ANCOVA with baseline plaque as a covariate.

Conditions

• Dental Plaque

Interventions

Type	Name	Description
DRUG	Stannous Fluoride Toothpaste (SnF)	Test toothpaste (0.454% SnF)
DRUG	Sodium Fluoride Dentifrice	Comparator toothpaste (0.243% NaF)

Timeline

• Start date: 2024-10-16
• Primary completion: 2024-12-04
• Completion: 2024-12-04
• First posted: 2026-02-19
• Last updated: 2026-02-19

Locations

1 site across 1 country: United States